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NIHR Signal Long-term macrolide antibiotics reduce risk of exacerbations of bronchiectasis
People with bronchiectasis (not caused by cystic fibrosis) who take long-term macrolide antibiotics are around 50% less likely to experience acute worsening of symptoms like cough and sputum production (an exacerbation) than people taking a placebo. Bronchiectasis guidelines only recommend preventative macrolide antibiotics in people with frequent exacerbations who do not carry a bacterium (Pseudomonas aeruginosa). This review pooled data from three trials in 341 patients where erythromycin or ...
NIHR Signal Questionnaires directed at smokers improve detection of chronic lung disease in general practice
Practices using questionnaires to identify individuals at risk of chronic obstructive pulmonary disease (COPD) increased the number of new cases found. In particular, posting questionnaires may be more effective than waiting for people to attend the GP surgery. Many people with COPD may dismiss or ignore symptoms such as chronic cough. Taking a more proactive approach with smokers or ex-smokers and not just waiting until people present with symptoms may mean earlier diagnosis. This can lead to ...
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