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NIHR Signal GLP-1 drug for diabetes gives modest cardiovascular benefits compared with placebo
Taking a glucagon-like peptide-1 receptor (GLP-1) agonist drug lowers the likelihood of having a stroke, heart attack or dying due to cardiovascular causes by 12%. The drugs give a similar 12% reduction in overall mortality. They do not increase the risk of heart failure, very low blood sugar levels or pancreatic disease. Diabetes causes one in five strokes along with other cardiovascular complications. Clinicians aim to reduce these risks and lower blood sugar levels. This meta-analysis is the...
NIHR Signal A behavioural intervention for obese pregnant women did not reduce risk of diabetes
This large NIHR-funded UK trial found that a behavioural intervention for obese pregnant women did not reduce their risk of developing diabetes during pregnancy, or having a baby born too large for the duration of pregnancy (large-for-dates). However, the intervention did reduce the mothers’ weight gain slightly and increased their physical activity. Women received advice about healthy eating and exercise alongside training in specific behavioural techniques. Hour-long sessions with a heal...
NIHR Signal Giving obese pregnant women metformin had no effect on baby’s weight at birth
A large trial found that giving obese pregnant women the diabetes drug, metformin, to prevent heavier babies, had no effect compared with an inactive dummy tablet. The trial was funded by the NIHR and Medical Research Council, and was the first to give metformin, a diabetes drug that is safe in pregnancy, to pregnant women without type 2 diabetes for this purpose. There are theoretical reasons why the medication may help in reducing a baby’s birthweight and previous studies had shown link...
NIHR Signal Weight-loss surgery dramatically reduces risk of diabetes
This NIHR-funded study found that very obese adults who had weight-loss surgery were 80% less likely to develop type 2 diabetes within 7 years than similar obese adults who did not have weight-loss surgery. The study data came from a large UK-wide database of general practices which was representative of the UK population. The treatment and monitoring of people in the study was realistic and typical of current routine clinical practice, increasing its applicability to the UK.
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