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NIHR Signal Lifestyle changes may be more important than drugs for mild hypertension
Consideration of wider risk factors may be important when treating adults with low-risk mild hypertension (raised blood pressure). A large NIHR-funded UK study compared rates of mortality and risk of cardiovascular disease between patients who received antihypertensive treatment and those who did not. There was an increased risk of adverse effects, like low blood pressure. It found no evidence to support starting drug treatment for adults of low-cardiovascular risk with mild hypertension. This...
NIHR Signal Two common operations to fix a broken tibia have similar outcomes
In people who had broken the lower part of their tibia (shin bone), fixation using a metal rod nailed to the insideof the bone was compared with a locking plate screwed onto the surface of the bone. There was no difference in the quality of life, disability or pain at 12 months for people who had fractures of the lower tibia fixed using either technique. NICE guidance recommends that surgery takes place within 24 hours of injury but does not mandate which type of surgery to perform. This NIHR U...
NIHR Signal Infant diets that include egg or peanut products appear to reduce food allergies
Certain allergenic foods introduced to an infant’s diet while weaning appear to reduce the chance of developing food allergies. This high quality review, including studies published this year, suggests that historical recommendations to delay the introduction of peanut and other allergenic foods to infant child’s diet in the first year of life may have been mistaken. The methodological limitations in some studies included in this review, reduce our certainty in the degree of benefit...
NIHR Signal Accuracy of staff who read mammograms doesn’t decline over time
Changing the order in which readers examine screening mammograms has no effect on breast cancer detection rates, rates of recall for further tests or rates of disagreement between readers. In the UK each woman’s mammogram is examined by two independent readers (radiologists, radiographers or breast clinicians) who review each batch of mammograms from about 40 women in the same order. Research in other fields has indicated that vigilance can decrease with increasing time spent performing a...
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