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NIHR Signal ‘Last resort’ antipsychotic remains the gold standard for treatment-resistant schizophrenia
Among patients with schizophrenia that has not responded to other drugs, the antipsychotic drug clozapine cuts the chances of hospital admissions and drugdiscontinuation. Recent trials have questioned the superior efficacy of clozapine compared with other standard antipsychotic drugs. However, a review of real-world data from observational studies confirms its place as a drug that may work when others fail. Patients prescribed clozapine had better outcomes, despite having more severe illness. ...
NIHR Signal Collaborative care can be moderately effective at treating depression regardless of physical health status
Collaborative care can be moderately effective at treating depression compared to usual care, whether or not people also have a long-term condition such as cancer or heart disease. Collaboration was provided by a case manager in primary care who was not a mental health professional. They coordinated a treatment plan with input from a GP and mental health professional. It is currently only recommended for people with depression and a long-term physical condition as prior to this review there was ...
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