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NIHR Signal Suction drainage after rectal cancer surgery does not reduce infection
Placing a suction drain in the pelvic cavity does not reduce the risk of pelvic infection after commonly-used surgery for rectal cancer. A French trial comparing results of surgery with and without pelvic drainage showed no difference in risk of infection within 30 days. The risk of infection was about 17%. The drainage technique is less commonly used in the UK. The study was carried out in several hospitals and included 469 people having total mesorectal excision of rectal cancer. Half the pat...
NIHR Signal Drugs that stimulate bone marrow might save lives in critically ill trauma patients
Erythropoiesis stimulating agents (ESAs) might improve survival of critically ill patients after trauma. These drugs are synthetic versions of erythropoietin, a natural hormone produced by the kidneys. They boost production of red blood cells from the bone marrow; however the survival effect seems to be independent of the effect on red cell production. ESA’s are already commonly used to treat anaemia associated with chronic kidney disease. This systematic review of trials in critical trau...
NIHR Signal Early oral feeding after stomach surgery is safe and reduces time spent in hospital
After upper gastrointestinal surgery, returning a patient to oral feeding on the day of the surgery, or the day after, is as safe as waiting for a few days. It also reduces the time the patient spends in hospital by about two days, potentially saving money. This systematic review and meta-analysis found no difference in adverse outcomes – such as leakage at the surgical site, need for re-insertion of a feeding tube, reoperations, readmissions or mortality – when adults were fed earl...
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