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NIHR Signal Delayed umbilical cord clamping reduces hospital mortality for preterm infants
Delays to clamping the umbilical cord of about a minute can reduce hospital mortality for preterm infants by around 32%. Delayed clamping also reduced the proportion of infants needing a blood transfusion by 10%. This review adds more precise data on survival from new trials including a large Australian trial (over 1,600 babies) to a previous Cochrane 2012 review of trails including 738 infants and provides new more precise data on the survival benefit. These findings are consistent with curre...
NIHR Signal Daily aspirin reduces pre-eclampsia for ‘at-risk’ women
Starting daily low-dose aspirin before 16 weeks of pregnancy in women at risk reduces pre-eclampsia, severe pre-eclampsia and foetal growth restriction. Aspirin started after 16 weeks is less beneficial, giving smaller risk reduction for pre-eclampsia and no effect on other outcomes. Defining who is ‘at risk’ remains challenging. Pre-eclampsia is a rare pregnancy complication, but one that can be dangerous for both mother and baby. Pregnant women are screened for pre-eclampsia risk ...
NIHR Signal Nitrofurantoin is as effective as other long-term antibiotics for preventing recurrent urinary tract infections
The antibiotic nitrofurantoin works as well as other long-term antibiotics for preventing recurrent urinary tract infections in women. However gastrointestinal side effects were more common in people on nitrofurantoin. The potential for inducing less antibiotic resistance compared to trimethoprim is a potential advantage of nitrofurantoin but this wasn’t a specified outcome for this review. This review of 12 trials, with 1,063 women, compared nitrofurantoin with other antibiotics such as ...
NIHR Signal Moderate exercise does not increase risk of preterm birth in healthy pregnant women
Women with an uncomplicated pregnancy who exercise are no more likely to have a preterm birth than those who don’t exercise. This systematic review pooled the findings of nine trials including 2059 healthy pregnant women who were assigned to exercise for 35 to 90 minutes, three to four times a week, or to no exercise. Despite previous concerns that exercise may increase risk of preterm birth, the review found no evidence for this. It also found that exercise might increase a woman’s...
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