NIHR DC Discover

Latest important health research summarised

Woman with COPD taking tablets

NIHR Signal Adding low dose theophylline to inhaled corticosteroids does not reduce COPD exacerbations

Taking low-dose theophylline tablets in addition to inhaled corticosteroids did not significantly reduce chronic obstructive pulmonary disease flare-ups (exacerbations). This NIHR funded study found that people taking the combination and those taking an inhaled steroid had the same number of exacerbations - just over two per year.

People who... Read More

  • 15 January 2019
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Man with depression looking out of window

NIHR Signal Combining mirtazapine with other antidepressants is not effective for treatment-resistant depression

Adding mirtazapine to first-line antidepressants for adults with treatment-resistant depression does not improve symptoms when compared with placebo (dummy pills). People taking mirtazapine are more likely to experience side effects, and stop taking their treatment.

This NIHR-funded trial took place in 106 general practices in England,... Read More

  • 15 January 2019
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Person having blood pressure taken

NIHR Signal The benefits of commonly used blood pressure and cholesterol lowering treatment can last 16 years

Fewer deaths from stroke had occurred in people who had high blood pressure treated with amlodipine, a calcium-channel blocker, compared to atenolol, 10 years after the end of a large trial. People with high blood pressure who took statins were less likely to die from cardiovascular diseases, such as heart disease or stroke than those taking a... Read More

  • 15 January 2019
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Elderly woman looking depressed with dementia

NIHR Signal Antidepressants do not help treat depression in people living with dementia

Antidepressants do not reduce symptoms of depression in people with dementia compared with placebo (dummy pills). Measured 6 to 13 weeks after starting the treatment, there is little or no difference in participants’ symptoms, but an increased chance of unwanted side effects. The review did not identify enough data to determine if... Read More

  • 8 January 2019
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Older lady with nurse at home discussing treatment.

NIHR Signal Home-based cardiac rehabilitation for heart failure has high rates of participation

Home-based cardiac rehabilitation for people with heart failure improves quality of life at 12 months compared with usual care. Among those allocated to rehabilitation, 90% remained in the programme – more than double average attendance rate for hospital-based rehabilitation. The average cost was estimated at £418 per participant which ... Read More

  • 8 January 2019
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