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Latest important health research summarised

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Oxygen Therapy

NIHR Signal High-flow nasal oxygen reduces reintubation after major surgery compared with conventional oxygen therapy

In adults after major surgery, high-flow nasal oxygen decreases by about two-thirds the need for reintubation compared with conventional oxygen therapy. In this study, only about four in every 100 patients needed reintubation with high-flow nasal oxygen, compared with about 11 in every 100 patients receiving conventional oxygen therapy.

This... Read More

  • 10 October 2019
  • Signal

Man taking tablet

NIHR Signal Short-term dual antiplatelet treatment may be best for most patients after receiving a drug-eluting stent

For patients who have had a drug-eluting stent inserted into the coronary arteries, there is no difference in mortality or cardiovascular outcomes between the standard 12-month dual antiplatelet therapy and shorter six-month courses. Longer courses above 12 months increased risk of bleeding and non-cardiac death compared with short courses.

It... Read More

  • 10 October 2019
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Male Patient

NIHR Signal Early suppression of male hormones is better than delayed therapy for advanced prostate cancer on balance

Offering early hormone suppression therapy to men with advanced prostate cancer that is causing no symptoms improves outcomes compared with waiting until symptoms of cancer spread arise. Early treatment is associated with 23 to 57 fewer deaths per 1,000 men over five years, depending on the men’s baseline risk. However, this comes with an... Read More

  • 2 October 2019
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Knee Replacement

NIHR Signal Partial knee replacement ‘could be first choice’ for suitable patients with osteoarthritis

Partial knee replacement surgery improves pain and function similarly to total knee replacement in people with osteoarthritis that affects only a single compartment of the knee. Partial knee replacement surgery is also cheaper.

In this NIHR-funded trial of 528 people with osteoarthritis affecting only one compartment of the knee, those who ... Read More

  • 2 October 2019
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Patient in hospital

NIHR Signal Better strategies are needed to reduce preventable patient harm in healthcare

About 6% of patients in healthcare settings internationally experience harm that could have been prevented. Around one in eight of these cases result in severe harm, causing permanent disability or death.

Drug errors, therapeutic management incidents and incidents involving invasive clinical procedures are the most common causes of preventable... Read More

  • 2 October 2019
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