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newborn baby

NIHR Signal C-reactive protein is not useful in diagnosing late-onset infection in newborns

The blood level of C-reactive protein (CRP), a marker indicating inflammation in the body, is not accurate enough alone to diagnose late-onset infection in newborn infants.

Late-onset neonatal infection, occurring more than three days after birth, is potentially serious and is relatively common. Tests measuring the blood level of CRP are widely ... Read More

  • 20 March 2019
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Older adults jogging

NIHR Signal Long-term exercise programmes reduce falls and injuries in older adults

Older people who participate in year-long exercise programmes fall less and are less likely to be injured if they do fall. Exercise does not increase or decrease their risk of hospitalisation. 

The people aged 60 or over (average age 73 years) who were included in this review took part in supervised training programmes. Typically, about... Read More

  • 19 March 2019
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treatment of Achilles tendon rupture

NIHR Signal Torn Achilles tendons have similar outcomes if treated with or without surgery

Outcomes for ruptured Achilles tendons appear similar irrespective of the choice of intervention. This systematic review and meta-analysis found that while the risk of re-rupture with corrective surgery was small at 2.3%, with conservative management (immobilisation in a cast), the rate was only 3.9%.

The complication rate at 4.9% was three... Read More

  • 19 March 2019
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Preterm baby in neonatal unit being monitored

NIHR Signal Brain scan may predict long-term disabilities in babies with brain injury

Magnetic resonance spectroscopy, a type of scan which shows brain biochemistry, could help predict whether there will be long-term effects of brain injury (encephalopathy) in new-born babies. It is usually done alongside an MRI.

Researchers scanned 82 babies being treated for brain injury, using MRI and also magnetic resonance spectroscopy. One ... Read More

  • 12 March 2019
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nurse talking to older woman in care home

NIHR Signal Antimicrobial stewardship programmes reduce antibiotic use in long-term care homes

Antimicrobial stewardship programmes have been found to reduce antibiotic use in long-term care residences by 14% when pooling evidence across a range of study types and interventions.  

Antimicrobial resistance is a public health threat, and overuse of antimicrobials is one of the main causes. Antimicrobial stewardship programmes are a... Read More

  • 12 March 2019
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