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Latest important health research summarised

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Medication

NIHR Signal Eplerenone does not improve vision in people with central serous chorioretinopathy

Eplerenone, a drug used for people with central serous chorioretinopathy, is no more effective than placebo. Neither visual acuity nor the build-up of fluid in the eye shows an important improvement.

Central serous chorioretinopathy is a serious eye condition that causes blurred and distorted vision. Fluid collects underneath the macula, which... Read More

  • 25 March 2020
  • Signal

Achilles Tendon

NIHR Signal Functional braces are effective alternatives to plaster casts for ruptured Achilles tendons

Early weight-bearing in a below-knee rigid boot, a functional brace, following ruptured Achilles tendon can achieve similar results to traditional plaster casting. This NIHR-funded trial included 540 people, and after nine months there appeared to be no difference between the two treatments in terms of how well patients recovered from their... Read More

  • 25 March 2020
  • Signal

Plasma injection

NIHR Signal Plasma and blood cell injections have not shown a benefit for Achilles tendon injury

Injecting a ruptured Achilles tendon with a small sample of a person’s own plasma, without the red blood cells, has no functional or other benefit. Plasma rich in platelets and white blood cells for the acute injury was compared with placebo.

The NIHR-funded trial involved 230 adults with acute Achilles tendon rupture (the tendon which... Read More

  • 18 March 2020
  • Signal

Broken Wrist X Ray

NIHR Signal Using wires to fix wrist fracture has good long-term outcome

Fixing a displaced broken wrist with wires is as effective as fixation with locking plates in the long term. Wrist function and pain continue to improve in the five years following either operation, with no evidence of a difference between the two treatments.

In 2014, a trial comparing the use of Kirschner wires and locking plates for... Read More

  • 18 March 2020
  • Signal

NIHR Signal Conventional fillings may not add much to standard prevention for decay in baby teeth

Sealing in decay, improving tooth hygiene and using conventional fillings all work to prevent future dental pain and infection for children with decay in baby teeth. The approaches are equally acceptable to children and parents.

Researchers tested three methods of managing decay in the primary molars of children aged three to seven:

  • 18 March 2020
  • Signal

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