NIHR DC Discover

Latest important health research summarised

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Older men playing football to keep fit

NIHR Signal A football programme for overweight men achieves sustained weight loss

A 12-week weight management programme for men, centred on football, achieved 4.9kg weight loss at 12 months. Modest weight loss of 2.9kg was maintained at 3.5 years.

Rates of overweight and obesity are higher for men than women in the UK, and there is little evidence that interventions are effective in the longer term. This NIHR-funded study... Read More

  • 16 October 2018
  • Signal

Man taking medication

NIHR Signal The blood-thinner apixaban is less likely to cause major bleeding than warfarin

People who take apixaban to prevent blood clots are less likely to suffer major bleeding complications than those taking warfarin. Findings are similar in different groups of people, such as those with irregular heart rhythm (atrial fibrillation) and those who have had joint replacement surgery.

Warfarin has long been used as an anticoagulant... Read More

  • 16 October 2018
  • Signal

Woman having an MRI scan

NIHR Signal MRI scan does not help to find the cause of pelvic pain in women

MRI scans are not sufficiently accurate to find the cause of chronic pelvic pain in women and should not replace laparoscopy (keyhole surgery), which can be used for diagnosis and often treatment. MRI only correctly ruled out a gynaecological condition in half of women judged to have no obvious cause and missed half of women who did have a... Read More

  • 16 October 2018
  • Signal

Someone holding an e-cigarette.

NIHR Signal Financial incentives may help workers quit smoking

Financial incentives, when given alongside free smoking cessation aids, improved abstinence rates compared with free cessation aids or motivational information alone. 

This workplace-based US trial assigned 6,000 smokers, unselected for willingness to quit, to information only, free e-cigarettes, free nicotine replacement or drug therapy,... Read More

  • 9 October 2018
  • Signal

Dressing on leg wound

NIHR Signal Negative pressure dressings are no better than standard dressings for open fractures

Negative pressure wound dressings are neither more nor less effective than standard wound dressings for severe open fractures of the lower leg. Any difference between groups was neither clinically important nor statistically significant. The outcomes included self-rated disability at one year, quality of life and deep surgical site infections at... Read More

  • 9 October 2018
  • Signal

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