Latest important health research summarised

NIHR Signal Early, intense rehabilitation helps recovery after serious traumatic head injury

Early, intensive rehabilitation aids recovery and improves outcomes for people with moderate to severe traumatic brain injury.

A review of 11 studies found that starting rehabilitation early, while people were still in intensive care, or offering more intensive treatments helped patients with brain injury regain function compared with usual... Read More

  • 19 June 2018
  • Signal

NIHR Signal Balanced electrolyte solutions give marginal benefit over saline for very ill patients

About 14% of critically ill patients receiving electrolyte-balanced crystalloids either developed kidney failure, needed kidney-replacement therapy or died compared with 15% receiving normal saline. This small but statistically significant benefit was only apparent when combining outcomes; there was no difference between fluids for the three... Read More

  • 19 June 2018
  • Signal

NIHR Signal Balance of long-term benefits and risks of caesarean delivery explained

Caesarean delivery has immediate known benefits and risks for those women who need help in childbirth. This review measures the long-term outcomes for the mothers’ health, the links to a higher risk of childhood illness and the chance of problems with future pregnancies.

The large review of 80 studies from high-income countries used data... Read More

  • 12 June 2018
  • Signal

NIHR Signal Single routine offer of a blood test for prostate cancer did not save lives

Offering all men aged 50 to 69 a single, screening prostate-specific antigen (PSA) blood test did not prevent deaths from prostate cancer.

This large trial included 573 UK general practices and over 400,000 men. It found that men who were invited to have a PSA test were 19% more likely to be diagnosed with prostate cancer, but no less likely to ... Read More

  • 12 June 2018
  • Signal

NIHR Signal Fewer side-effects and similar benefits from shorter chemotherapy after bowel cancer surgery

A three-month course of chemotherapy after surgery for bowel cancer seems no less effective than the standard six-month course, and half as many people suffered from nerve damage as a side-effect. Three-quarters of people survived to three years without disease progression on either treatment.

This international trial, part funded by the NIHR,... Read More

  • 12 June 2018
  • Signal

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